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양한방융합기반기술개발사업:

  • 2016년 1월 6일
  • 1분 분량

연구주제 : 간암동물모델에서 한약복합제의 항암효과 및 면역증강 효능 평가

지원부처 : 보건복지부

연구기간 : 2015.06~2019.05


 
 
 

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Journal Articles

 

Extracellular vesicles as drug delivery vehicles for rheumatoid arthritis. Curr Stem Cell Res Ther 2016, In Press.

 

Comparison of molecular profiles of human mesenchymal stem cells from different sources – bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med 2016, 37: 115-125

 

Globular adiponectin induced leukocytosis and mobilizes hematopoietic progenitor cells in mice. Tissue Eng Reg Med 2015, 12(6):449-456.  

 

Adiponectin inhibits mouse mammary tumor growth and reduced tumor-induced hematopoiesis. Tissue Eng Reg Med 2015, 12(5):324-330.

 

Flt3 ligand induces monocyte proliferation and enhances the function of monocyte-derived dendritic cells in vitro. J Cell Physiol. 2015, 230(8):1740-1749.

 

Progranulin and a five transmembrane domain-containing receptor-like protein are the key components in receptor activator of nuclear factor Kb (RANK)-dependent formation of multinucleated ssteoclasts. J Biol Chem. 2015, 290(4):2042-52.

 

PSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts. Stem Cell Reports. 2015, 4(5):821-34.

 

Characteristics of circulating CD31(+) cells from patients with coronary artery disease. J Cell Mol Med. 2014, 18(11):2321-30.

 

CD31(+) cell transplantation promotes recovery from peripheral neuropathy. Mol Cell Neurosci. 2014, 62:60-7.

 

Metabolomic approaches to the normal aging process. Metabolomics 2014, 10:1268-1292.

 

PSA-NCAM(+) neural precursor cells from human embryonic stem cells promote neural tissue integrity and behavioral performance in a rat stroke model. Stem Cell Rev. 2014, 10(6):761-71.

 

Erythropoietic potential of CD34+ hematopoietic stem cells from human cord blood and G-CSF-mobilized peripheral blood. Biomed. Res. Int. 2014:435215.

 

Identification of pancreatic cancer-associated tumor antigen from HSP-enriched tumor lysate-pulsed human dendritic cells. Yonsei Med. J. 2014, 55(4):1014-1027.

 

Highly fluorescent conjugated polyelectrolyte for protein sensing and cell-compatible chemosensing applications. ACS Appl Mater Interface 2014, 6(5):3305-3311.

 

Non-invasive photodetachment of stem cells on tunable conductive polymer nano thin films: selective harvesting and preserved differentiation capacity. ACS Nano 2013, 7(5):4119-4128.

 

Mesenchymal stem cell-derived secretome and microvesicles as a cell-free therapeutics for neurodegenerative disorders. Tissue Eng. Reg. Med. 2013, 10(3): 93-101.

 

Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke. Neuroscience 2013, 238: 305–318.

 

Duration of in vitro storage affects the key stem cell features of human bone marrow-derived mesenchymal stromal cells for clinical transplantation. Cytotherapy. 2013, 15(4):460-466.

 

Stem cells as promising therapeutic options for neurological disorders. J Cell Biochem. 2013, 114(4):743-753.

 

ABCD2 is a direct target of b–catenin and TCF-4: Implications for X-linked adrenoleukodystrophy. PLoS One 2013, 8(2):e56242.

 

The genetically modified polysialylated form of neural cell adhesion molecule-positive cells for potential treatment of X-linked adrenoleukodystrophy.  Yonsei Med J 2013, 54(1):246-252.

 

A randomized trial of mesenchymal stem cells in multiple system atrophy. Annals Neurol. 2012,  72(1):32–40

 

Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery. Exp. Mol. Med. 2012, 44(3):202-213.

 

Adiponectin induces dendritic cell activation via PLCγ/JNK/NF-κB pathways, leading to Th1 and Th17 polarization. J. Immunol. 2012, 188(6):2592-2601.

 

Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J. Proteome Res. 2012, 11(2): 839-849.

Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes. PLoS One. 2012;7(7):e39715.

 

Immunotherapy of malignant melanoma with tumor lysate-pulsed autologous monocyte-derived dendritic cells. Yonsei Med. J. 2011, 52(6): 990-998.

 

Serum cytokine profiles in healthy young and elderly population assessed using multiplex bead-based immunoassay. J Transl Med. 2011, 9:113.

 

Protein coverage on polymer nanolayers leading to mesenchymal stem cell patterning. Phys. Chem. Chem. Phys. 2011, 13, 17625-17632.

 

Micropatterns of double-layered nanofiber scaffolds with dual functions of cell patterning and metabolite detection. Lab Chip 2011, 11(17):2849-2857.

 

Induced Pluripotent Stem Cell Models from X-linked Adrenoleukodystrophy Patients. Annals Neurol. 2011, 70(33) 402-409.

 

Comparison of endothelial progenitor cells in Parkinson's disease patients treated with Levodopa and Levodopa/COMT inhibitor. PLOS One 2011, 6(6): e21536.

 

Aging-associated decline in innate immunity and therapeutic strategies to counteract it. Tissue Eng. Reg. Med. 2011, 8(2):124-132.

 

In vitro hepatic differentiation potential of human cord blood-derived mesenchymal stem cells. Int. J. Mol. Med. 2011, 27: 701-706.

 

Isolation of mesenchymal stem cells from the mononuclear cells remaining in the bone marrow processing kit. Korean J. Blood Transfus. 2010, 21: 280-288.

 

Fast and efficient isolation of mouse bone marrow-derived mesenchymal stem cells by using a biocompatible polymer. Tissue Eng. Reg. Med. 2010, 7(4): 443-451.

 

Enhanced neovascularization by simultaneous transplantation of peripheral blood CD34+ hematopoietic stem cells and CD14+ monocytes. Tissue Eng. Reg. Med. 2010, 7(2): 223-229.

 

Monocyte enrichment from leukapheresis products by using the Elutra® cell separator. Transfusion 2007, 47(12): 2290-2296.

 

High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation in Pediatric Patients with High-risk Neuroblastoma. Korean J Blood Transfus. 2007, 18:227-238

 

Magnetic poly 1-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model. J. Drug Targeting 2007, 15(6): 445-453.

 

The farnesyltransferase inhibitor, LB42708, inhibits growth and induces apoptosis irreversibly in H-ras and K-ras transformed rat intestinal epithelial cells. Toxicol. Appl. Pharmacol. 2006, 215: 317-329.

 

Enhancement of antitumor immunity of dendritic cells pulsed with heat-treated tumor lysate in murine pancreatic cancer. Immunol. Lett. 2006, 103(2):142-148.

 

Differences in immune cells engaged in cell-mediated immunity after chemotherapy for far advanced pancreatic cancer. Pancreas 2006, 32:29-36. 

 

Frequent mutations of Human MAD2, but not hBUB1, in gastric cancers cause defective mitotic spindle checkpoint. Mutation Res. 2005, 578:187-201.

 

Isolation of endothelial progenitor cells from cord blood and induction of differentiation by ex vivo expansion. Yonsei Med. J. 2005, 46: 260-267.

 

Strategies to improve dendritic cell-based immunotherapy against cancer. Yonsei Med. J. 2004, 45S: 48-52.

 

Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study. Oncol. Reports 2004, 12: 33-39.

 

Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells. Biochem. Biophys. Res. Comm. 2003, 310: 433-438.

 

Ex vivo expansion of human umbilical cord blood CD34+ cells in a collagen bead-containing 3-dimensional culture system. Int. J. Hematol. 2003, 78: 126-132.

 

Role of acinar cell in hamster pancreatic carcinogenesis. Korean J. Gastroenterol. 2003, 41: 138-144.

 

Expression of integrin a5. a6. aV, b1, b3, b4 subunits in gastric cancer. Korean J. Gastroenterol. 2002, 40: 355-363.

 

Altered expression of Lewis antigen on tissue and erythrocytes in gastric cancer patients. Yonsei Med. J. 2002, 43: 427-434.

 

Immunotherapeutic strategies for cancer: cell-based approaches. Exp. Mol. Med. 2002, 34S: 185-201.

 

Differential induction of cytokine genes and activation of mitogen-activated protein kinase family by soluble CD40 ligand and TNF in a human follicular dendritic cell line. J. Immunol. 1999, 163, 631-638.

 

Isolated human germinal center centroblasts have an intact mismatch repair system. J. immunol. 1998, 161, 6128-6132.

 

The functional role of B cell antigen receptor stimulation and IL-4 in the generation of human memory B cells from germinal center B cells. J. Immunol. 1997, 159, 3757-3766.

 

Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells: Anti-Ig down-regulates Fas expression on CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis. J. Immunol. 1996, 157: 1006-1016.

 

Stimulation of germinal center B lymphocyte growth by a FDC-like cell line, HK. J. Immunol. 1995, 155, 1101-1109.

 

Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes. J. Immunol. 1994, 153, 2951-2961.

 

Effects of cyclosporine and rapamycin on immunoglobulin production by preactivated human B cells. Clin. Exp. Immunol. 1994, 96, 508-512.

 

Cyclosporine A and prednisolone inhibit lectin and alloantigen-induced release of sCD8: correlation with proliferative responses. Clin. Immunol. Immunopathol. 1991, 60, 27-39.

 

Books

 

A Guide to Safer Cell Therapy Products, 2011. Yonsei Univeristy.  ISBN 978-89-7141-971-7

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